COMT polymorphism and memory dedifferentiation in old age.
نویسندگان
چکیده
منابع مشابه
COMT polymorphism and memory dedifferentiation in old age.
According to a neurocomputational theory of cognitive aging, senescent changes in dopaminergic modulation lead to noisier and less differentiated processing. The authors tested a corollary hypothesis of this theory, according to which genetic predispositions of individual differences in prefrontal dopamine (DA) signaling may affect associations between memory functions, particularly in old age....
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The C957T polymorphism in the dopamine D2 receptor (DRD2) gene and the Val158Met polymorphism in the Catechol-O-Methyl-Transferase (COMT) gene affect dopamine transmission and have been found to be associated with schizophrenia. Since DRD2 in mice and the COMT gene in humans modulate working memory, we examined the relationship and possible interaction of both polymorphisms to working memory pe...
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متن کاملDopamine and memory dedifferentiation in aging
The dedifferentiation theory of aging proposes that a reduction in the specificity of neural representations causes declines in complex cognition as people get older, and may reflect a reduction in dopaminergic signaling. The present pharmacological fMRI study investigated episodic memory-related dedifferentiation in young and older adults, and its relation to dopaminergic function, using a ran...
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ژورنال
عنوان ژورنال: Psychology and Aging
سال: 2014
ISSN: 1939-1498,0882-7974
DOI: 10.1037/a0033225